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Effox ® 20, 40 Tablets

Effox provides long-term treatment of coronary artery diseases (ex: Angina pectoris), its is composed of Isosorbide mononitrate; unlike dinitrates it has no first pass metabolism , thus providing 100% Bioavailability with an onset of action within 20 minutes of administration, and a dose of one tablet twice daily.

Ingredient: Isosorbide-5-mononitrate
Multinational Partner: Schwarz Pharma
Launch Date: August 1, 1992
Pack: Box of 20 Tablets

Product General

Disease Area
  • Long-term treatment of coronary artery disease.
  • Long-term treatment of angina pectoris (even after treated myocardial infarction).
  • Long-term treatment of chronic heart failure in combinaiton with cardiac glycosides, diuretics, ACE-inhibitors or arterial vasodilators.
  • Pulmonary hypertension.
Insert leaflet


Isosorbide 5-mononitrate 20/40 mg; scored tablets.
It possesses an intrinsic prolonged action. Unlike the isosorbide dinitrate, there is no first pass metabolism & minimal individual plasma level variations. Long-term treatment of coronary artery disease. Prophylaxis of anginal attacks. Post-treatment of myocardial infarction with persisting anginal symptoms. Long-term treatment of chronic congestive heart failure in combination with digitalis and/or diuretics. Chronic cor pulmonale.
Side Effects
Rarely nitrate headache may develop and could be avoided if treatment is started with 1/2 tablet twice daily.
Dosage and Administration
One tablet, 1st dose 8 am, last dose 4 pm, to provide a nitrate-free interval. Nitrate free interval means no tolerance development.

Packaging: 20 tablets


1-Documents Section

Efficacy of ISMN VS GTN

Nitrates for stable angina

Effect of ISMN on angina patients


In the Most recent Guidelines of the European Society of Cardiology (SCAD) for the management of Stable Coronary Aretry Disease (SCAD);

Nitrates were recommended for the relief of Angina/ Ischaemia.

Attached Files

Esc 2013-SCAD.PDF
Mechanism of action movie

1-Video Section

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